Dosing ERROR at AstraZeneca-Oxford University vaccine trial led to huge boost in jab’s success rate

  • AstraZeneca scientist Mene Pangalos says ‘serendipity,’ led to a break through 
  • ‘Mistake’ helped scientists discover half-dose was more effective than a full one 
  • More analysis needed to explain why an initial lower dose was more effective

A dosing error by researchers on the AstraZeneca-Oxford University vaccine trial led to a huge boost in the jab’s success rate, the firm’s vice president has revealed.

Mene Pangalos, head of AstraZeneca’s non-oncology research and development, said: ‘The reason we had the half dose is serendipity.’

Volunteers in Britain were expected to receive two full doses of the vaccine as it was trialed in the hope of funding a cure.

Dr Pangalos says researches were perplexed when they noticed volunteers were reporting much milder side effects, such as fatigue, headaches and arm aches, than were originally predicted.  

He said: ‘So we went back and checked … and we found out that they had underpredicted the dose of the vaccine by half.’

Dr Mene Pangalos, from AstraZeneca, revealed a ‘mistake,’ led to one volunteer group receiving half of their first dose – but scientists later discovered that dosage was more effective than a full one

He said the team nonetheless decided to press ahead with that half dose group, and to administer the second, full dose booster shot at the scheduled time.

The results showed the vaccine was 90 per cent effective among this group, while a larger group who had received two full doses produced an efficacy read-out of 62%, leading to an overall efficacy of 70% across both dosing patterns, Pangalos said.

‘That, in essence, is how we stumbled upon doing half dose-full dose (group),’ he told Reuters. 

‘Yes, it was a mistake.’

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The vaccine uses a harmless adenovirus to deliver genetic material that tricks the human body to produce proteins known as antigens that are normally found on the coronavirus surface, helping the immune system develop an arsenal against infection.

Pangalos said more analysis was needed to explain why an initial lower dose bolstered protection. 

One possible explanation was that lower antigen levels to begin with triggered an overall better immune system build-up, he added.  

Oxford University confirmed its cheap, easy to store and simple to deliver jab could be approved by regulators in as little as a fortnight and start to be administered next month. 

Britain has ordered 100million doses of the Oxford Universty vaccine, with almost 20million due by Christmas

Britain has ordered 100million doses, with almost 20million due by Christmas.

Andrew Pollard, head of the Oxford Vaccine Group and a professor who has spent two decades running clinical trials, said that while speed of the COVID-19 vaccine’s development was in some ways extraordinary, 2020 had ‘been a very long year’ since the team started work on the vaccine in January.

That culminated this past weekend, Pollard said, in having ‘an enormous mountain to climb to pull all of the information together’ to be able to issue Monday’s data release showing the vaccine can

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The 7 Most Promising Government Led AI Solutions

As the 21st century rages on, success and failure of nations depends not only on their citizenry and governmental leadership, but heavily on the technological visions that countries embrace. If a nation takes the approach of sitting back or standing still as automation and Artificial Intelligence advance at ever increasing rates, that nation is destined to be left behind. However, if a country embraces AI and dedicates significant resources and top minds to ethical implementation, that country is destined to be a leader for decades to come.

Recently Steve Mills, Chief AI Ethics Officer & Leader for Artificial Intelligence in the Public Sector, and Partner at Boston Consulting Group said quite eloquently “AI has become table stages for global national economic and technological competitiveness. This goes beyond nations capturing a piece of the large and rapidly growing AI market. AI is poised to transform nearly every industry. There is an imperative for nations to position themselves to integrate AI into these sectors. Particularly those sectors that are economically important to them. Failing to do so could erode their competitive position, creating opportunities for other, more technologically advanced nations to fill the void. This is not just a matter of missed upside potential from the new AI market. It’s also about downside risk for every other sector that is economically important to a nation.” 

What does it take to be one of these leading nations? To find that answer let’s look at the 7 most promising Governmental AI solutions across the globe. 

1. United States Department of Defense Joint Artificial Intelligence Center

The Pentagon’s Joint Artificial Intelligence Center is building on its success and moving towards what its Director, Marine Corps Lt. Gen. Michael Groen, calls “JAIC 2.0.” He wants the United States to accelerate the implementation of AI within the DoD. Lt. General Groen has also overseen the granting of $100 million to Deloitte Consulting to create a Joint Common Foundation to help organize the pentagon’s AI factory, secure it against intruders, direct its workers and test its products. As I’ve written ad infinitum, countries will always move their vision forward by successfully teaming with the private sector. 

2. Denmark’s Digital Growth

The Danish government allocated $134 million euros through 2025 as a part of their new Digital Growth Strategy. The goal of Denmark’s strategy for digital growth is to make Denmark a pioneer in the digital revolution to develop wealth for every Danish citizen. 

This sounds great on its face, but what exists within their borders to make this a reality? PerLasse Grøn Christensen, a

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College Football Playoff race after Week 9 led by Alabama, Clemson

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USA TODAY Sports’ Paul Myerberg breaks down the latest Amway Coaches Poll.

USA TODAY

It’s taken Ohio State just two weeks to turn the race for the Big Ten championship into a mere formality.

The Buckeyes have put together easy wins against Nebraska (52-17) and Penn State (38-25) as quarterback Justin Fields has surged into prime Heisman Trophy contention.

Even the 13-point edge over the Nittany Lions, if impressive on its own, doesn’t do justice to the Buckeyes’ dominance of a projected Big Ten championship contender.

Combined with what’s happened elsewhere in the conference — namely Michigan’s stunning loss to rival Michigan State — this high level of play has Ohio State on a clear track for the College Football Playoff.

Ohio State wide receiver Garrett Wilson (5) runs past Nebraska safety Deontai Williams during the second half at Ohio Stadium. (Photo: Joseph Maiorana, USA TODAY Sports)

Typically released in early November, the debut playoff rankings were scheduled for Nov. 17 but then moved back to Nov. 24 to accommodate this unique regular season. With the Pac-12 not beginning play until this weekend, the one-week delay was suggested by commissioner Larry Scott as a way to give the conference an additional data point with the selection committee.

RE-RANK: Michigan takes major tumble in this week’s 1-127

HIGHS AND LOWS: College football winners and losers from Week 9

MISERY INDEX: Michigan loss to Michigan State is worst of Harbaugh era

The Pac-12 may factor into the postseason debate. Oregon in particular has the talent and depth to go unbeaten in conference play, though it’s impossible to predict how the committee will perceive and compare teams with varying numbers of games played — in fact, that may end up being the defining issue of the championship race.

While awaiting the entry of the Pac-12, the playoff race has started to take focus. Unsurprisingly, three national powers have already staked a spot in the field.

Here’s how the top four would look today, followed by the four teams just on the outside:

1. Alabama: Want one example of Alabama’s SEC supremacy? Senior DeVonta Smith has more receiving yards (203) than Mississippi State had total yards (200) in the Crimson Tide’s 41-0 shutout.

2. Clemson: D.J. Uiagalelei isn’t the only five-star freshman making a difference for the Tigers. Defensive linemen Myles Murphy and Bryan Breese have combined for 46 tackles, 11 tackles for loss, 6½sacks and 10 quarterback pressures.

3. Ohio State: Fields has six touchdowns and seven incompletions. Two of those incomplete throws were drops in the end zone by Ohio State receivers. 

4. Notre Dame: With surprisingly little attention, the Fighting Irish own the nation’s longest active winning streak at 12 games.

5. Georgia: Coach Kirby Smart will again be forced to answer questions about his choice at quarterback after Stetson Bennett threw two interceptions in a sloppy 14-3 win against Kentucky. At the least the Georgia defense is playing at a championship level.

6. Cincinnati: And speaking of good

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18 Trump rallies have led to 30,000 COVID-19 cases: Stanford University study

A new study from Stanford University found that 18 of President TrumpDonald John TrumpBiden leads Trump in survey of Texas voters from left-leaning pollster On The Trail: Making sense of Super Poll Sunday Trump rebukes FBI for investigating supporters accused of harassing Biden bus MORE’s campaign rallies have led to over 30,000 confirmed coronavirus cases and likely led to over 700 deaths. 

Researchers examined rallies held between June 20 and Sept. 22, 2020, only three of which were held indoors.

The researchers then compared spread of the virus in the counties that held the rallies to counties that were on similar case trajectories before the rallies occurred. 

The authors concluded that the rallies increased subsequent cases of COVID-19 by over 250 infections per 100,000 residents. They found that the events led to over 30,000 new cases in the country and likely resulted in over 700 deaths, but recognized that the deaths were “not necessarily among attendees.” 

“Our analysis strongly supports the warnings and recommendations of public health officials concerning the risk of COVID-19 transmission at large group gatherings, particularly when the degree of compliance with guidelines concerning the use of masks and social distancing is low,” the authors wrote in the paper. “The communities in which Trump rallies took place paid a high price in terms of disease and death.

The study was published to preprint platform SSRN on Friday. 

In a statement to The Hill, the Trump campaign deputy national press secretary Courtney Parella said that, “Americans have the right to gather under the First Amendment to hear from the President of the United States.” 

‘We take strong precautions for our campaign events, requiring every attendee to have their temperature checked, providing masks, they’re instructed to wear, and ensuring access to plenty of hand sanitizer,” Parella said. “We also have signs at our events instructing attendees to wear their masks.”

Biden campaign spokesperson Andrew Bates said in a statement to The Hill that Trump is “costing hundreds of lives and sparking thousands of cases with super spreader rallies that only serve his own ego.” 

The study comes as the U.S. set a new single-day record for coronavirus cases on Friday, logging 97,080 new cases according to COVID Tracking Project, shattering the previous record of 88,521 on set Thursday.

The study results come as public health experts have warned that the fall and winter seasons could lead to a disastrous third wave of coronavirus cases as the colder weather forces people to congregate indoors. 

The president, however, has repeatedly dismissed the new surge in cases, claiming that the nation is “rounding the turn” on the pandemic. He has also blamed the media for the intense focus on COVID-19.

On Friday, he drew backlash for claiming that doctors are improperly counting coronavirus deaths for personal and monetary gain. 

Trump has drawn scrutiny for holding rallies with thousands of mostly unmasked people despite the pandemic. Supporters at his rallies are also not seen social distancing. 

One of

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College football midseason awards led by Ttrevor Lawrence, Mac Jones

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USA TODAY Sports’ Paul Myerberg breaks down the latest Amway Coaches Poll.

USA TODAY

Only in 2020 would college football’s midseason hit as one Power Five conference has played a single game and another league is more than a week away from kickoff.

While the Big Ten just got started and the Pac-12 won’t open until Nov. 7, the 2020 season began Sept. 5 and has heated up since the SEC opened on Sept. 26.

Despite the odd and mismatched schedules across Bowl Subdivision leagues, one aspect of the season has gone according to plan: Alabama and Clemson have carved out some distance from the rest of pack in the early College Football Playoff race.

Also predictable? That Clemson quarterback Trevor Lawrence would head into Halloween as the favorite for the Heisman.

As we reach the midway point, here’s a look at the players, teams, coaches and games that have defined the first half of the 2020 season.

Best player

Paul Myerberg: Clemson QB Trevor Lawrence. He’s completing 70.7% of his attempts, averaging 9.6 yards per throw and avoiding turnovers (two interceptions in 191 throws) at a better rate than in 2019. This is an easy pick.

Erick Smith: Alabama QB Mac Jones. Any thought that the Crimson Tide offense would be slowed by the departure of Tua Tagovailoa can be discarded. It might actually be better with Jones off to an amazing start. The junior threw for 417 yards and four touchdowns against an elite Georgia defense in a comeback win. He ranks third in passing yards and passer efficiency. 

Alabama quarterback Mac Jones throws under pressure from Georgia defensive lineman Devonte White during the second half at Bryant-Denny Stadium. (Photo: Gary Cosby Jr, The Tuscaloosa News)

Coach of the year

Paul Myerberg: Luke Fickell, Cincinnati. Fickell turned down the chance to take over at Michigan State in part because he knew what the No. 7 Bearcats were capable of achieving in 2020. Cincinnati already has two wins against Top 25 competition and have a shot at rising into the top four.

Erick Smith: Chris Klieman, Kansas State: With a roster devastated by COVID-19, the Wildcats lost their opener against Arkansas State. Two weeks later, they rallied to beat Oklahoma. That was the first of four Big 12 victories in a row. His next challenge will be overcoming the loss of starting quarterback Skylar Thompson and make the conference title game.

BOWL PROJECTIONS: Big Ten’s opening weekend shakes up playoff outlook

HEISMAN WATCH: Lawrence, Jones lead voting, while Fields moves up

IN JEOPARDY: Wisconsin close to having to cancel game against Nebraska

Best defender

Paul Myerberg: Notre Dame LB Jeremiah Owusu-Koramoah. The senior has made splash plays for one of the nation’s best defenses and a unit already being compared to some of the best in recent program history. He’s second on the team with 21 tackles and leads with six tackles for loss.

Erick Smith: Arkansas LB Grant Morgan. The Razorbacks have been one of the stories

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Chip Scale Package LED Market Research Report by Power Range, by Application – Global Forecast to 2025

Chip Scale Package LED Market Research Report by Power Range (High-Power and Low- & Mid-Power), by Application (Automotive Lighting, Backlighting Unit (BLU), Flash Lighting, and General Lighting) – Global Forecast to 2025 – Cumulative Impact of COVID-19

New York, Oct. 22, 2020 (GLOBE NEWSWIRE) — Reportlinker.com announces the release of the report “Chip Scale Package LED Market Research Report by Power Range, by Application – Global Forecast to 2025 – Cumulative Impact of COVID-19” – https://www.reportlinker.com/p05913818/?utm_source=GNW

The Global Chip Scale Package LED Market is expected to grow from USD 830.28 Million in 2019 to USD 2,015.16 Million by the end of 2025 at a Compound Annual Growth Rate (CAGR) of 15.92%.

Market Segmentation & Coverage:
This research report categorizes the Chip Scale Package LED to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Power Range, the Chip Scale Package LED Market studied across High-Power and Low- & Mid-Power.

Based on Application, the Chip Scale Package LED Market studied across Automotive Lighting, Backlighting Unit (BLU), Flash Lighting, and General Lighting.

Based on Geography, the Chip Scale Package LED Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Company Usability Profiles:
The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Chip Scale Package LED Market including Cree, Inc., DOW Chemical Company, Epistar Company, Flory Optoelectronic Materials Company, Genesis Photonics, Lextar Electronics, LG Innotek, Lumens Co., Ltd., Lumileds, Nichia Corporation, Osram Opto Semiconductors, Samsung Electronics, Semileds Corporation, and Seoul Semiconductor.

FPNV Positioning Matrix:
The FPNV Positioning Matrix evaluates and categorizes the vendors in the Chip Scale Package LED Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Competitive Strategic Window:
The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.

Cumulative Impact of COVID-19:
COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The

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