Ascendis Pharma A/S Announces Presentations for its Endocrinology Rare Disease Clinical Programs at Upcoming Medical Conferences

COPENHAGEN, Denmark, Oct. 21, 2020 (GLOBE NEWSWIRE) — Ascendis Pharma A/S (Nasdaq: ASND), a biopharmaceutical company that utilizes its innovative TransCon™ technologies to address unmet medical needs, today announced five presentations featuring the company’s endocrinology rare disease programs at two upcoming medical conferences: European Calcified Tissue Society (ECTS) 2020, taking place online October 22–24, 2020, and the Pediatric Endocrinology Nursing Society (PENS) national conference, taking place online November 2–5, 2020.

During ECTS, results from the phase 2 PaTH Forward Trial of TransCon PTH in adult hypoparathyroidism (HP) will be presented. During PENS, data from the phase 3 fliGHt Trial of TransCon hGH (lonapegsomatropin) in pediatric growth hormone deficiency (GHD) and from two clinical trials of the auto-injector for lonapegsomatropin. Additionally, the company will present posters highlighting the impact of achondroplasia (ACH) on the quality of life in children and their parents, which will help inform the TransCon CNP program.

“Ascendis Pharma is committed to supporting the endocrinology community, and we are excited to present data across all three of our endocrinology rare disease programs,” said Aimee Shu, M.D., Senior Medical Director, Clinical Development at Ascendis Pharma. “The data being presented at this year’s ECTS and PENS meetings highlight our portfolio of investigational product candidates and demonstrate important clinical and quality of life outcomes for patients and caregivers, including our first presentation of clinical data on our proprietary auto-injector for lonapegsomatropin.”

Presentation Details

ECTS

Poster Presentation

Title

 

Date/Time

 

Design and Topline Results of TransCon PTH, a Long-acting Parathyroid Hormone (PTH), Phase 2 Trial in Patients with Hypoparathyroidism

 

Presented on Saturday, October 24, 2020 at 4:55–5:00 p.m. (CST) with live Q&A to follow.

 

PENS 2020

Poster Presentations

Title

 

Date/Time

 

Introduction of a Novel GH Auto-Injector for Once-weekly Administration of TransCon hGH (lonapegsomatropin)

 

Posters are available during PENS with live Q&A on Thursday, November 5, 2020 from 2:15–2:45 p.m. (ET).

 

Treatment Experience of Children with Growth Hormone Deficiency in the Phase 3 fliGHt Trial: Switching from Daily Growth Hormone to Once-weekly TransCon hGH (lonapegsomatropin)

 

 

Pediatric Achondroplasia: Impacts on Children’s Functioning and Well-being

 

 

Experiences of Parents of Children with Achondroplasia: Impacts on Quality of Life

 

 

The posters will be available on the Ascendis website under Selected Publications in the Pipeline section: https://ascendispharma.com/product-pipeline/publications/.   If you are a healthcare provider who would like more information, please contact: [email protected]

About TransCon™ Technology Platform

TransCon refers to “transient conjugation.” The proprietary TransCon platform is an innovative technology to create new therapies that are designed to potentially optimize therapeutic effect, including efficacy, safety and dosing frequency. TransCon molecules have three components: an unmodified parent drug, an inert carrier that protects it, and a linker that temporarily binds the two. When bound, the carrier inactivates and shields the parent drug from clearance. When injected into the body, physiologic conditions (e.g., pH and temperature) initiate the release of the active, unmodified parent drug in a predictable manner. Because the parent drug is unmodified, its original mode of action is expected to be maintained. TransCon technologies can be