A joint research team led by Prof. Wang Hui and Prof. Lin Wenchu from the High Magnetic Field Laboratory of the Hefei Institutes of Physical Science developed a synthesis of metal-free multifunctional therapeutic reagents, called graphitic carbon nitride quantum dots embedded in carbon nanosheets (CNQD-CN), via a one-step hydrothermal treatment.
Metal-free multifunctional nanomaterials have broad application prospects in integrated cancer diagnosis and treatment.
The team took an organic solvent (formamide) as the carbon and nitrogen source and then developed CNQD-CN.
CNQD-CN can be utilized as a near-infrared (NIR)/pH dual-responsive drug delivery system to improve the response to chemotherapy. It possesses both light-to-heat conversion and singlet oxygen generation capabilities under a single NIR excitation wavelength for combined photodynamic and photothermal therapy.
“The combination of graphitic carbon nitride quantum dots and two-dimensional carbon-based nanomaterials might be a potential candidate for realizing imaging-guided synergistic cancer therapy due to its excellent performance, including optical properties, efficient light-to-heat conversion capability, and near-infrared (NIR)-induced singlet oxygen generation,” said Wang Hui, who designed the project.
However, synthesis of related nanocomposites, including multiple reaction precursors, complex synthesis processes, potential weak interaction, produced large amounts of waste, thus limiting their scalable production and reproducibility.
This study was a further step in realizing the advantages of imaging-guided synergistic cancer therapy.
Biocompatible TeSex nano-alloys for PT/PA/CT/PET imaging-guided NIR-II-photothermal therapy
Hongji Liu et al, Graphitic Carbon Nitride Quantum Dots Embedded in Carbon Nanosheets for Near-Infrared Imaging-Guided Combined Photo-Chemotherapy, ACS Nano (2020). DOI: 10.1021/acsnano.0c05143
Scientists propose potential method for imaging-guided synergistic cancer therapy (2020, October 15)
retrieved 15 October 2020
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.